Clinical Chemistry current issue

[Editorials] CSF Serine Enantiomers and Glycine in the Study of Neurologic and Psychiatric Disorders
Hashimoto, K. Thu, 28 Aug 2008 00:00:00 -0000

[Editorials] Saliva Analysis for Monitoring Dialysis and Renal Function
Nagler, R. M. Thu, 28 Aug 2008 00:00:00 -0000

[Editorials] Coffee Consumption and Coronary Heart Disease: Paradoxical Effects on Biological Risk Factors versus Disease Incidence
van Dam, R. M. Thu, 28 Aug 2008 00:00:00 -0000

[Perspective] Evaluating New Diagnostic Technologies: Perspectives in the UK and US
Price, C. P., Christenson, R. H. Thu, 28 Aug 2008 00:00:00 -0000

[Mini-Review] Defining a Role for Novel Biomarkers in Acute Coronary Syndromes
Bonaca, M. P., Morrow, D. A. Thu, 28 Aug 2008 00:00:00 -0000
Background: Biomarkers play a pivotal role in the diagnosis and treatment of patients with cardiovascular disease. Active investigation has brought forward an increasingly large number of novel candidate markers; however, few of these markers have yet to be incorporated into routine clinical use. Content: This review discusses biomarkers currently used in the setting of acute coronary syndromes. In this context, we assess the contemporary unmet needs for novel biomarkers in acute ischemic heart disease and the related challenges faced in developing new biomarkers to the point of integration into clinical practice. In particular, we address the impact of the availability of increasingly sensitive biomarkers of myocardial necrosis on the potential roles for novel biomarkers of inflammation, thrombosis, and ischemia. Summary: Although active investigation has produced a growing list of candidate novel biomarkers for the care of patients with cardiovascular disease, it has become increasingly challenging to find appreciable incremental clinical benefit for their addition to existing markers, in particular newer, more analytically sensitive cardiac troponin assays. A major challenge for researchers and clinicians will be to demonstrate whether candidate novel markers are useful in improving diagnosis and guiding clinical treatment.
[Review] Key Issues in the Developing Synergism between Cardiovascular Imaging and Biomarkers
Jaffe, A. S. Thu, 28 Aug 2008 00:00:00 -0000
Background: Sophisticated methods of cardiac imaging have the potential to revolutionize the care of patients with cardiovascular disease. The benefits of these state-of-the art imaging techniques can be enhanced by their use in combination with new cardiac biomarkers. This review addresses potentially useful interactions between imaging and biomarkers. Content: Areas were defined in which the combined use of novel imaging techniques and biomarkers would be most beneficial. This review addresses multiple cardiovascular conditions for which the useful aspects of imaging and biomarkers are likely to be positively synergistic, including acute and chronic ischemic heart disease, heart failure, myocarditis, hypertension, and atherosclerosis. Conclusions: The synergistic use of imaging techniques and biomarkers will enhance the investigation of many key issues and questions and will be an important resource in the future.

 

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Inorganic Chem Lab - Organometallic chemistry of f- and d-block transition metal complexes, chemistry of boron clusters, carboranes and metallacarboranes, homogenous catalysis and coordinative unsaturation, small molecule activation and polymer synthesis .

Abell Group - Pantothenate biosynthesis and chemistry and enzymology of the shikimate pathway.

Adronov Group - Synthesis of novel polymer architectures. Carbon nanotube functionalization. Supramolecular polymer chemistry.

404 Anslyn Group - Physical and bioorganic chemistry of synthetic and natural receptors and catalysts.

Bagchi Group - Theoretical studies of dynamical processes in liquids, biopolymers and glasses.
Meta Description: [ Research group of Prof. Biman Bagchi at Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore, India. ]

Baiker Group - Heterogeneous catalysis.
Meta Description: [ ETH Zuerich ]

Balch Group - Synthetic and structural chemistry of transition metals, catalysis, polynuclear metal complexes, metalloporphyrins, fullerene chemistry, bioinorganic chemistry.

Bernstein Group - Study of intermolecular interactions and their effects on molecular properties and behavior.
Meta Description: [ We present studies on the following topics: Covariance Mapping, V, Ti, Ag Oxide/Halide,Neurotransmitter/~cluster, Optical & Time-of-Flight Mass Spectroscopy, Plasma Chemistry, CVD Chamber Cleaning, and much more ]

404 Bertozzi Group - Cell surface glycosylation. Biomaterial and interfacial design.
Meta Description: [ Carolyn Bertozzi's research group homepage. Our lab at UC Berkeley studies cell surface interactions that contribute to human health and disease with specific projects in the areas of cancer, inflammation and bacterial infection. In addition, we also have a lab at the Lawrence Berkeley National... ]

Bluemel Group - Immobilization of catalysts with phosphine linkers. Surface organometallic chemistry. Solid-state NMR spectroscopy.
Meta Description: [ Prof. Dr. Janet Bluemel's Work Group ]

Bowser Biotechnology Lab - Neuromessenger monitoring. In vitro evolution of functional biomolecules.

Chemical Sciences Division - US Department of Energy sponsored projects at Oak Ridge National Laboratory, Tennessee.

Chemometrics Group - Homepage of the Chemometrics Research Group at the University of Silesia, Poland.
Meta Description: [ Homepage of Department of Chemometrics at Institute of Chemistry, University of Silesia ]

Dalton Group - High technology electronic, Electro-optic, and nonlinear optical materials.

Davis Group - Synthetic methodology. Molecular recognition. Supramolecular chemistry. Catalysis. Computer-aided molecular design.

Deck Group - Organometallic chemistry aiming at making interesting and useful contributions to the frontiers of chemistry at the complex four-way intersection of organometallic, physical organic, polymer, and organofluorine chemistry.

404 DiSalvo Group - Extended solids based on metal clusters. Chemistry of ternary nitrides. Thermoelectric coolers.
Meta Description: [ FW4 DW4 HTML ]

Dovichi Group - Laser based microchemical analysis, capillary separation techniques, bioanalytical chemistry.

Doyle Group - Transition metal catalysts and development of chiral catalysts.

Dupas Group - Synthesis of biomimetic models of NADH and the molecular recognition of acids and amines.

Dutta Group - Harsh environment sensor development, synthesis and photochemistry of microporous materials and atmospheric particle toxicity.

Dynamic Stereochemistry and Chirality Laboratory - Chiral HPLC separations. Data mining. Theoretical models of enantioselection. Synthesis of new chiral stationary phases.
Meta Description: [ Dynamic Stereochemistry and Chirality Laboratory of Prof Roussel Marseille ]

Freund Group - Material science and analytical chemistry.

Friend Group - Heterogeneous catalysis, nanostructure growth, environmental chemistry, laser-assisted materials processing, and chemical sensor technology.

Gilson Group - Noncovalent binding and molecular recognition.
Meta Description: [ Molecular Modeling and Informaticsat the Gilson Lab, CARB, Rockville, MD ]

Gordon Group - Deposition of thin films using alternating layer deposition and chemical vapor deposition.
Meta Description: [ Welcome to the website of the Roy Gordon research group at the Harvard University Department of Chemistry and Chemical Biology. We specialize in the deposition of thin films using alternating layer deposition and chemical vapor deposition. ]

404 Grapperhaus Group - Metal-thiolate chemistry.

Griesbeck Group - Photooxygenation of organic compounds. Photocycloaddition reactions: stereoselectivity and spinselectivity. Photodecarboxylation, photoisomerization, and photocyclization reactions of imides. Photochemical macrocyclization reactions. New photochemical reactors and technologies.

Grinstaff Group - Novel biomaterials.
Meta Description: [ The Mark W. Grinstaff research group pursues highly interdisciplinary research in the areas of biomedical engineering and macromolecular chemistry. ]

Hamers Group - Interfacial architecture.

Hartgerink Group - Supramolecular chemistry. Autowiring nanocircuits. Self-assemblying ECM. Biomineralization.

Hilvert Group - Chemical biology.
Meta Description: [ Homepage of Prof. Dr. D. Hilvert and his research group, working in the field of chemical biology at the Federal Institute of Technology (ETH) Zurich ]

Hites Group - Environmental chemistry.
Meta Description: [ We apply organic analytical chemistry to the understanding of environmental problems. Almost all of our work uses gas chromatographic mass spectrometry for the analysis of trace levels of potentially toxic environmental pollutants. ]

Hudson Group - Molecular electronic and vibrational spectroscopy.

Huhnerfuss Group - Ecotoxicology, biota-analysis, water-analysis, sediment-analysis, remote sensing, and Langmuir monolayer.

Hult Group - Dendritic polymers. Macromolecular nano cylinders. Biofibers.

Hutchison Group - New chemical building blocks. Green chemistry.

Iran Polymer and Petrochemical Institute - IPPI - Government organization involved in applied research in polymer science and technology, and education.

500 Ireland Group - Marine natural product drug discovery.

Irmgard Frank Group - Investigates highly reactive systems with first-principles simulations.
Meta Description: [ The quantum chemistry group (Dr. Irmgard Frank) at the Institute of Physical Chemistry, LMU München, investigates highly reactive systems with first-principles simulations. ]

Jarrold Group - Biological mass spectrometry. Biophysics of peptides and proteins. Characterization of metal and semiconductor clusters.

Kahr Group - Chemical crystallography.
Meta Description: [ Professor Bart Kahr's Homepage, University of Washington, Department of Chemistry, Seattle ]

Kohen Group - Enzymatic catalysis in biological systems.

Laboratory for Computational and Applied Chemistry - Molecular and engineering catalysis. Molecular modeling and drug design.

Laboratory of Biotransformation - Integrates both chemical and biological disciplines, including chemical modifications and biotransformations.

Laser Flash Photolysis Group - Reactive organic intermediates in solid state (zeolites) and solution systems. Physical bio-organic chemistry and the examination of enzyme active-site/reactive-intermediate complexes.

Lee Group - Organic–inorganic materials. Transition metal catalysts. Bioinorganic modeling.

Liquid Crystal Group Hamburg - Chiral liquid crystals, organic materials and glycolipids. Access to LiqCryst database.

Matyjaszewski Group - Atom transfer radical polymerization (ATRP) and other methods of controlled radical polymerization (CRP).
Meta Description: [ Krzysztof Matyjaszewski, ATRP, CRP, Atom Transfer Radical Polymerization, Center for Macromolecular Engineering, CRP Consortium, Controlled Radical Polymerization ]

McDevitt Group - Development of microchip sensors suitable for detection / quantification of acids, bases, salts, sugars, proteins, viruses, and DNA oligomers.

Meyer Group - Supramolecular, organometallic and bioinorganic chemistry.

Mitchell Group - Molecular aggregation, protein ligand-interactions, prediction of molecular properties, and the molecular basis of odor.

Munro Group - Synthesis and characterization of novel metalloporphyrins by X-ray, spectroscopic, and computational methods.

Nanomechanics Group - Molecular Mechanisms underlying the biological activity of proteins. Mechanical properties of polymer molecules.

Palczewski Group - Molecular events initiated by light in photoreceptor cells.
Meta Description: [ Our laboratory at the University of Washington studies the molecular events initiated by light in vertebrate photoreceptor cells. Biochemical, functional, and genetic aspects of phototransduction and retinoid cycles that are critical for the restoration of the dark condition of these sensory cell... ]

Pérot Group - Petroleum refining and fluorine chemistry.
Meta Description: [ The web site describes the activities in the fields of petroleum refining and of fluorine chemistry of the group « Sulfides and oxides » (team manager : Guy PEROT) belonging to the « Laboratoire de Catalyse en Chimie Organique » (LACCO) of the University of Poitiers. ]

Reymond Group - Catalytic peptide dendrimers. Enzyme assays and fingerprints. Small molecule enzyme inhibitors.

Richards Group - Design and synthesis of novel structures for application in catalysis and nanotechnology.

500 Schreiber Group - Signal transduction pathways. PIK-related kinases and the histone deactylases (HDACs).

Schrock Group - Synthetic and mechanistic organotransition metal. Inorganic chemistry. Catalysis. Polymers.

Schwartz Group - Interface chemistry: surface modification of inorganic conductor or semiconductor surface and development of strong interfaces between metallic surfaces and biomolecules.

Shevelkov Group - Synthesis, crystal and electronic structure, and properties of solid state supramolecular and cluster compounds.

Simmons Group - X-ray diffraction of cobalt/iron-dioxygen complexes and copper (II) Jahn-Teller complexes.
Meta Description: [ University of Hawaii at Hilo X-Ray Diffraction laboratory ]

404 Storch Group - Study of structure and bonding of tin-nitrogen compounds. Investigation of the mummification process of ancient egyptian mummies.

Strouse Group - Integrated design and optical spectroscopy of nanometer-scale materials.
Meta Description: [ We are a research group in the Department of Chemistry and Biochemistry at Florida State University. The principle focus of our research is the integrated design and optical spectroscopy of nanometer-scale materials. ]

Structural Chemistry Group - Opto-electronic and sensor devices.
Meta Description: [ universiteit antwerpen - Structural Chemistry ]

Swager Group - Supramolecular and materials chemistry.

Taton Group - Nanobiotechnology: hybrid materials from nanoscale objects and biomolecules. Nanotube composites: aligning soft mesophases with hard nanostructures. Novel bioanalytical methods using nanoparticle-based materials.

The Molecular Structure and Detection Group - Mass spectrometry, cluster ion chemistry, molecular spectroscopy and modelling of the ro-vibrational states of small molecules.
Meta Description: [ experimental and theoretical research in chemistry ]

Theoretical Inorganic Chemistry Group - Dynamics of metal oxide surfaces.
Meta Description: [ Theoretical Inorganic Chemistry homepage ]

Theoretical Study of Reaction Mechanisms - Investigation of reaction mechanisms by non-empirical quantum mechanical methods.

Trenary Group - Structure and chemistry of solid surfaces. Heterogeneous catalysis, semiconductor processing, growth of thin film materials, and nanotechnology.

Vicic Group - Selective and catalytic organic transformations. Synthetic inorganic chemistry. Bio-inorganic coordination chemistry.

404 Volkmer Group - Biomimetic and bioinorganic chemistry.
Meta Description: [ Main Index Page ]

Waters Group - Noncovalent interactions and their effect on structural specificity and chemical reactivity.

Whitesides Group - Physical and organic chemistry, materials science, biophysics, complexity, surface science, microfluidics, self-assembly, micro- and nanotechnology, science for developing economies, origin of life, and cell-surface biochemistry.
Meta Description: [ The George Whitesides Research Group in the Department of Chemistry and Chemical Biology at Harvard University, Cambridge, Massachusetts, USA. High Impact Innovation and Imagination. ]

Wright Group - Design of novel solids for use as shape-selective sorbents and catalysts.
Meta Description: [ The Wright Group conduct research into porous solids within the School of Chemistry, University of St. Andrews. ]