Clinical Chemistry current issue

[Editorials] CSF Serine Enantiomers and Glycine in the Study of Neurologic and Psychiatric Disorders
Hashimoto, K. Thu, 28 Aug 2008 00:00:00 -0000

[Editorials] Saliva Analysis for Monitoring Dialysis and Renal Function
Nagler, R. M. Thu, 28 Aug 2008 00:00:00 -0000

[Editorials] Coffee Consumption and Coronary Heart Disease: Paradoxical Effects on Biological Risk Factors versus Disease Incidence
van Dam, R. M. Thu, 28 Aug 2008 00:00:00 -0000

[Perspective] Evaluating New Diagnostic Technologies: Perspectives in the UK and US
Price, C. P., Christenson, R. H. Thu, 28 Aug 2008 00:00:00 -0000

[Mini-Review] Defining a Role for Novel Biomarkers in Acute Coronary Syndromes
Bonaca, M. P., Morrow, D. A. Thu, 28 Aug 2008 00:00:00 -0000
Background: Biomarkers play a pivotal role in the diagnosis and treatment of patients with cardiovascular disease. Active investigation has brought forward an increasingly large number of novel candidate markers; however, few of these markers have yet to be incorporated into routine clinical use. Content: This review discusses biomarkers currently used in the setting of acute coronary syndromes. In this context, we assess the contemporary unmet needs for novel biomarkers in acute ischemic heart disease and the related challenges faced in developing new biomarkers to the point of integration into clinical practice. In particular, we address the impact of the availability of increasingly sensitive biomarkers of myocardial necrosis on the potential roles for novel biomarkers of inflammation, thrombosis, and ischemia. Summary: Although active investigation has produced a growing list of candidate novel biomarkers for the care of patients with cardiovascular disease, it has become increasingly challenging to find appreciable incremental clinical benefit for their addition to existing markers, in particular newer, more analytically sensitive cardiac troponin assays. A major challenge for researchers and clinicians will be to demonstrate whether candidate novel markers are useful in improving diagnosis and guiding clinical treatment.
[Review] Key Issues in the Developing Synergism between Cardiovascular Imaging and Biomarkers
Jaffe, A. S. Thu, 28 Aug 2008 00:00:00 -0000
Background: Sophisticated methods of cardiac imaging have the potential to revolutionize the care of patients with cardiovascular disease. The benefits of these state-of-the art imaging techniques can be enhanced by their use in combination with new cardiac biomarkers. This review addresses potentially useful interactions between imaging and biomarkers. Content: Areas were defined in which the combined use of novel imaging techniques and biomarkers would be most beneficial. This review addresses multiple cardiovascular conditions for which the useful aspects of imaging and biomarkers are likely to be positively synergistic, including acute and chronic ischemic heart disease, heart failure, myocarditis, hypertension, and atherosclerosis. Conclusions: The synergistic use of imaging techniques and biomarkers will enhance the investigation of many key issues and questions and will be an important resource in the future.

 

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404 A Proton NMR Shielding Model for the Face of a Phenyl Ring - Slide show.

Alexander Pines - Links to titles of publications and brief Description of their work on remote detection, xenon biosensors, flow imaging, microfluidics, alternative detection methods etc.

College of Chemistry NMR Facility - Experiment oriented website From Rudi Nunlist's group. Radiation Damping, CPD, presaturation, calibration of decoupling pulse and numerous other topics. Explanations and experimental parameters for several 1D and 2D experiments, e.g., inverse 2D experiments, deuterium decoupling etc.

Course Notes - EMBO Practical Course on Structure Determination by NMR Course notes (pdf) - EMBO Practical NMR Course 2003

404 Diffusion - Topicwise list of diffusion related references and a list of NMR diffusometry links.

EPR spectroscopy (Electron Paramagnetic Resonance) - Lectures, slide presentations and thesis on the theory and applications of pulsed and solid state ESR spectroscopy (electron spin resonance) by Gunnar Jeschke. (PDF files)

Functional Magnetic Resonance Imaging of the Brain - A thesis written by Stuart Clare of the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain. Extensive theory of FMRI.

gt; 10,000 times in liquid-state NMR PNAS -- Abstracts: Ardenkj Larsen et al. 100 (18): 10158 - Hyperpolarization in the liquid state created by dissolving a solid sample that has been polarized by dynamic nuclear polarization (DNP) at low temperature in a high magnetic field.

High performance computations in NMR - Description of theoretical and computational methods for calculating the evolution of magnetization (classical) and density operator (quantum mechanical)

404 hyperpolarized xenon in biology by Andrea Cherubini and Angelo Bifone - Review (Progress in NMR spectroscopy)

METAFoR: J. Bact -- Reprint (PDF) Version: Sauer et al. 181 (21):6679 - Metabolic Flux Ratio Analysis of Genetic and Environmental Modulations of Escherichia coli Central Carbon Metabolism

404 NMR of Oriented Molecules - A list of references.

NMR shielding tensor - Perturbational relativistic theory of NMR nuclear shielding and spin-spin coupling tensors (Uses Breit-Pauli Hamiltonian in the Dirac equation). Thesis of Pekka Manninen.
Meta Description: [ Pekka Manninen. Breit-Pauli Hamiltonian and Molecular Magnetic Resonance Properties ]

PNAS -- Reprint (PDF) Version: Frydman et al. 99 (25):15858 - Multidimensional NMR spectra within a single scan.

Principles and demonstrations of quantum information processing by NMR spectroscopy - Quantum computing using macroscopic pseudo-pure states described by some of the pioneers in this field.(pdf)

Quantum computing using NMR - Principles and critical assessment of prospects for use of magnetic resonance phenomena in quantum computing

Quantum computing using nmr - A paper describing the use of high resolution NMR theory and techniques for performing quantum computation. By D.Cory, A.Fahmy and T.Havel. Downloadable postscript file.

Quantum computing, cross correlation - Publication list of Prof. Anil Kumar. Links to his recent original papers and reviews on 'Quantum computing using NMR' and 'theory of cross correlation' (links to pdf files).

TROSY: PNAS -- Reprint (PDF) Version: Pervushin et al. 94 (23):12366 - Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution. By Konstantin Pervushin, Roland Riek, Gerhard Wider, and Kurt Wüthrich