For the British rock band of the same name, see Amplifier (band)

An amplifier can be considered to be any device that uses a small amount of energy to control a source of a larger amount of energy, although the term today usually refers to an electronic amplifier. The relationship of the input to the output of an amplifier — usually expressed as a function of the input frequency — is called the transfer function of the amplifier, and the magnitude of the transfer function is termed the gain.

General characteristics of amplifiers

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Most amplifiers can be characterised by a number of parameters.

Gain

How much an amplifier increases the signal level is called the gain. This is usually measured in decibels (dB). Mathematically speaking, the gain is equal to the output level divided by the input level. (for power gain in decibels gain is computed by the relation G(dB)=10log(Pout/Pin)(Electrical)).

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Background: The human kallikrein-related peptidase (KLK) family consists of 15 highly conserved serine proteases, which are encoded by the largest uninterrupted cluster of protease genes in the human genome. To date, several members of the family have been reported as potential cancer biomarkers. Although primarily known for their biomarker value in prostate, ovarian, and breast cancers, more recent data suggest analogous roles of KLKs in several other cancers, including gastrointestinal, head and neck, lung, and brain malignancies. Among the proposed KLK cancer biomarkers, prostate-specific antigen (also known as KLK3) is the most widely recognized member in urologic oncology. Content: Despite substantial progress in the understanding of the biomarker utility of individual KLKs, the current challenge lies in devising biomarker panels to increase the accuracy of prognosis, prediction of therapy, and diagnosis. To date, multiparametric KLK panels have been proposed for prostate, ovarian, and lung cancers. In addition to their biomarker utility, emerging evidence has revealed a number of critical functional roles for KLKs in the pathogenesis of cancer and their potential use as therapeutic targets. Summary: KLKs have biomarker utility in many cancer types but individually lack sufficient specificity or sensitivity to be used in clinical practice; however, groups of KLKs and other candidate biomarkers may offer improved performance.
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