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The history of chemistry may be said to begin with the distinction of chemistry from alchemy by Robert Boyle in his work The Sceptical Chymist (1661). Both alchemy and chemistry are concerned with the nature of matter and its transformations but, in contrast with alchemists, chemists apply the scientific method. The history of chemistry is intertwined with the history of thermodynamics, especially through the work of Willard Gibbs.

Early developments


Origins

Although the archives of chemical research draw upon work from ancient Babylon, Egypt, and especially Persia after Islam, the birth of chemistry is often dated to Antoine Lavoisier's discovery of the law of conservation of mass, and thereby to his refutation of the phlogiston theory of combustion in 1783. (Phlogiston was supposed to be an imponderable substance liberated by flammable materials in burning.) Mikhail Lomonosov independently established a tradition of chemistry in Russia in the 18th century. Lomonosov also rejected the phlogiston theory, and anticipated the kinetic theory of gases. He regarded heat as a form of motion, and stated the idea of conservation of matter.

The vitalism debate and organic chemistry

After the nature of combustion (see oxygen) was settled, another dispute, about vitalism and the essential distinction between organic and inorganic substances, was revolutionized by Friedrich Wöhler's accidental synthesis of urea from inorganic substances in 1828. Never before had an organic compound been synthesized from inorganic material. This opened a new research field in chemistry, and by the end of the 19th century, scientists were able to synthesize hundreds of organic compounds. The most important among them are mauve, magenta, and other synthetic dyes, as well as the widely used drug aspirin. The discovery also contributed greatly to the theory of isomerism.

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