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Nickel is a metallic chemical element in the periodic table that has the symbol Ni and atomic number 28.

Notable characteristics


Nickel is a silvery white metal that takes on a high polish. It belongs to the iron group, and is hard, malleable, and ductile. It occurs combined with sulfur in millerite, with arsenic in the mineral niccolite, and with arsenic and sulfur in nickel glance.

On account of its permanence in air and inertness to oxidation, it is used in the smaller coins, for plating iron, brass, etc., for chemical apparatus, and in certain alloys, as German silver. It is magnetic, and is very frequently accompanied by cobalt, both being found in meteoric iron. It is chiefly valuable for the alloys it forms, especially many superalloys.

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Background: The human kallikrein-related peptidase (KLK) family consists of 15 highly conserved serine proteases, which are encoded by the largest uninterrupted cluster of protease genes in the human genome. To date, several members of the family have been reported as potential cancer biomarkers. Although primarily known for their biomarker value in prostate, ovarian, and breast cancers, more recent data suggest analogous roles of KLKs in several other cancers, including gastrointestinal, head and neck, lung, and brain malignancies. Among the proposed KLK cancer biomarkers, prostate-specific antigen (also known as KLK3) is the most widely recognized member in urologic oncology. Content: Despite substantial progress in the understanding of the biomarker utility of individual KLKs, the current challenge lies in devising biomarker panels to increase the accuracy of prognosis, prediction of therapy, and diagnosis. To date, multiparametric KLK panels have been proposed for prostate, ovarian, and lung cancers. In addition to their biomarker utility, emerging evidence has revealed a number of critical functional roles for KLKs in the pathogenesis of cancer and their potential use as therapeutic targets. Summary: KLKs have biomarker utility in many cancer types but individually lack sufficient specificity or sensitivity to be used in clinical practice; however, groups of KLKs and other candidate biomarkers may offer improved performance.
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eh all the winos affectionately refer to it as The Nickel. So this is kind of a hobo's lullaby." ... tom waits on the nickel ...
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