Clinical Chemistry current issue

[Editorials] CSF Serine Enantiomers and Glycine in the Study of Neurologic and Psychiatric Disorders
Hashimoto, K. Thu, 28 Aug 2008 00:00:00 -0000

[Editorials] Saliva Analysis for Monitoring Dialysis and Renal Function
Nagler, R. M. Thu, 28 Aug 2008 00:00:00 -0000

[Editorials] Coffee Consumption and Coronary Heart Disease: Paradoxical Effects on Biological Risk Factors versus Disease Incidence
van Dam, R. M. Thu, 28 Aug 2008 00:00:00 -0000

[Perspective] Evaluating New Diagnostic Technologies: Perspectives in the UK and US
Price, C. P., Christenson, R. H. Thu, 28 Aug 2008 00:00:00 -0000

[Mini-Review] Defining a Role for Novel Biomarkers in Acute Coronary Syndromes
Bonaca, M. P., Morrow, D. A. Thu, 28 Aug 2008 00:00:00 -0000
Background: Biomarkers play a pivotal role in the diagnosis and treatment of patients with cardiovascular disease. Active investigation has brought forward an increasingly large number of novel candidate markers; however, few of these markers have yet to be incorporated into routine clinical use. Content: This review discusses biomarkers currently used in the setting of acute coronary syndromes. In this context, we assess the contemporary unmet needs for novel biomarkers in acute ischemic heart disease and the related challenges faced in developing new biomarkers to the point of integration into clinical practice. In particular, we address the impact of the availability of increasingly sensitive biomarkers of myocardial necrosis on the potential roles for novel biomarkers of inflammation, thrombosis, and ischemia. Summary: Although active investigation has produced a growing list of candidate novel biomarkers for the care of patients with cardiovascular disease, it has become increasingly challenging to find appreciable incremental clinical benefit for their addition to existing markers, in particular newer, more analytically sensitive cardiac troponin assays. A major challenge for researchers and clinicians will be to demonstrate whether candidate novel markers are useful in improving diagnosis and guiding clinical treatment.
[Review] Key Issues in the Developing Synergism between Cardiovascular Imaging and Biomarkers
Jaffe, A. S. Thu, 28 Aug 2008 00:00:00 -0000
Background: Sophisticated methods of cardiac imaging have the potential to revolutionize the care of patients with cardiovascular disease. The benefits of these state-of-the art imaging techniques can be enhanced by their use in combination with new cardiac biomarkers. This review addresses potentially useful interactions between imaging and biomarkers. Content: Areas were defined in which the combined use of novel imaging techniques and biomarkers would be most beneficial. This review addresses multiple cardiovascular conditions for which the useful aspects of imaging and biomarkers are likely to be positively synergistic, including acute and chronic ischemic heart disease, heart failure, myocarditis, hypertension, and atherosclerosis. Conclusions: The synergistic use of imaging techniques and biomarkers will enhance the investigation of many key issues and questions and will be an important resource in the future.

 

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Australian Computational Chemistry Via the Internet Project - A set of web-based teaching modules.
Meta Description: [ ACCVIP Computational Chemistry via the Internet Project ]

Cambridge University Silicon Graphics Teaching Laboratory - An outline of a course in computational chemistry. Includes exercises in conformational search, molecular dynamics, visualization, and databases.

CMM - Center for Molecular Modeling: Several tutorials related to molecular modeling, directory of software and links to databases.

Computational Chemistry and Organic Synthesis - A tutorial intended for experimental organic chemists, with emphasis on computational methods for locating and characterizing transition states.

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Meta Description: [ Ideal-gas thermochemistry. Comparisons between theory and experiment. ]

Computational Chemistry List - A resource for computational chemists. Discussions on chemistry software, data, conferences, jobs, quantum chemistry, molecular mechanics, molecular dynamics, QSAR, molecular graphics, molecular modeling, and associated archives

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500 Computational Chemistry Roadmap - Identifies future scientific challenges in computational chemistry from the perspective of the U.S. chemical industry.

Doubly Nudged Elastic Band Method - A framework for finding transition states based on the nudged elastic band method, balancing accuracy with efficiency.
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First Principles Research, Inc. - Research Theorists in Physics and Chemistry.
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Intertek ASG Computational Chemistry Group - Services provided by the group include the calculation of molecular properties using computational chemistry, the management, analysis, visualisation and modelling of data, training, consultancy and problem solving.
Meta Description: [ Intertek ASG Computational Chemistry Group: extensive expertise and experience in traditional computational chemistry and dealing with complex data. Services provided by the group include calculation of molecular properties using computational chemistry, the management, analysis, visualisation an... ]

MathMol - Provides students, teachers and researchers the basic concepts in mathematics and their connection to molecular modeling. Links to Software, 3D libraries and tutorials.

MatHub - Features current and background information about molecular modeling and informatics for chemistry and materials science.
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Molecular Docking Web - Protein-ligand Docking, structures, bioinformatics, computational chemistry, and drug design resources.
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Molecular Modeling - Links to information on chemical structures, graphics, slide shows, and modeling experiments.
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500 Molecular Modeling for Organic Chemistry - Summary of lecture course which aims to introduce the hierarchy of computational modeling methods used in Organic Chemistry. Links to background and supplemental information.