Gourt > Science > Chemistry > Analytical > Mass Spectrometry (8)
Mass spectrometry is an analytical technique used to measure the mass-to-charge ratio of ions. It is most generally used to find the composition of a physical sample by generating a mass spectrum representing the masses of sample components. The technique has several applications, including:
- identifying unknown compounds by the mass of the compound molecules or their fragments
- determining the isotopic composition of elements in a compound
- determining the structure of a compound by observing its fragmentation
- quantifying the amount of a compound in a sample using carefully designed methods (mass spectrometry is not inherently quantitative)
- studying the fundamentals of gas phase ion chemistry (the chemistry of ions and neutrals in vacuum)
- determining other physical, chemical or even biological properties of compounds with a variety of other approaches
A mass spectrometer is a device used for mass spectrometry, and produces a mass spectrum of a sample to find its composition. This is normally achieved by ionizing the sample and separating ions of differing masses and recording their relative abundance by measuring intensities of ion flux. A typical mass spectrometer comprises three parts: an ion source, a mass analyzer, and a detector.
How it works: simple example
Different chemicals have different masses, and this fact is used in a mass spectrometer to determine what chemicals are present in a sample. For example, table salt (NaCl), is vaporized (turned into gas) and ionized (broken down) into electrically charged particles, called ions, in the first phase of the mass spectrometry. The sodium ions and chloride ions have specific atomic weights. They also have a charge, which means that their path can be controlled with an electric or magnetic fields. The ions are sent into an acceleration chamber and passed through a slit in a metal sheet. A magnetic field is applied to the chamber. The field pulls each ion with equal force and deflects them (makes them curve instead of travelling straight) onto a detector. The lighter ions deflect farther than the heavy ions because according to the Newton's second law of motion the acceleration of a particle is inversely proportional to its mass. The detector measures exactly how far each ion has been deflected, and from this measurement, the ion's 'mass to charge ratio' can be worked out. From this information it is possible to determine with a high level of certainty the chemical composition of the original sample. More on [ Mass spectrometry ]
MALDI Mass Spectrometry for Synthetic Polymer Analysis (Chemical Analysis: A Series of Monographs on Analy⦠- by Liang Li http://j.mp/4M4a5d
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MALDI Mass Spectrometry for Synthetic Polymer Analysis (Chemical Analysis: A Series of Monographs on Analy… - by Liang Li http://j.mp/4M4a5d
Recent Content > SDS-PAGE and Mass Spectrometry Are Together At Last - http://eepurl.com/fHXc
matthewwygant (Matthew Wygant) Thu, 10 Dec 2009 00:47:30 -0000
Recent Content > SDS-PAGE and Mass Spectrometry Are Together At Last - http://eepurl.com/fHXc
MALDI Mass Spectrometry for Synthetic Polymer Analysis (Chemical Analysis: A Series of Monographs on Analy⦠- by Liang Li http://j.mp/5DuzCj
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MALDI Mass Spectrometry for Synthetic Polymer Analysis (Chemical Analysis: A Series of Monographs on Analy… - by Liang Li http://j.mp/5DuzCj
MALDI Mass Spectrometry for Synthetic Polymer Analysis http://bit.ly/5eZcua
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MALDI Mass Spectrometry for Synthetic Polymer Analysis http://bit.ly/5eZcua
#PPL_2010 Synlab Group Selects Bruker's MALDI Biotyper System for Mass Spectrometry-based Molecular Mi.. http://bit.ly/5sXxcM
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#PPL_2010 Synlab Group Selects Bruker's MALDI Biotyper System for Mass Spectrometry-based Molecular Mi.. http://bit.ly/5sXxcM
A.N. Hoffnagle: Quantitative Clinical Proteomics by Liquid ChromatographyâTandem Mass Spectrometry: Assessing the Platform http://ow.ly/JDOI
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A.N. Hoffnagle: Quantitative Clinical Proteomics by Liquid Chromatography–Tandem Mass Spectrometry: Assessing the Platform http://ow.ly/JDOI
Harsh-Environment Mass Spectrometry - Biannual four day workshop, including applications under-water and in outer space, with abstracts and presentations at Sarosota, Florida.
I-Mass - Resource featuring monthly focus, mass spectrometry journals and books, conferences, history, guides, software and laboratories.
Meta Description: [ mass spectrometry, mass spectrometry resource, international mass spectrometry resource ]
IMSC 2006 - Details of 17th International Mass Spectrometry Conference held for six days in Prague, Czech Republic.
Meta Description: [ Information about News ]
Introduction to Mass Spectrometry - Definitions and biological applications at Astbury Centre for Structural Molecular Biology, University of Leeds, England.
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LCMS Montreux Symposium - International Association of Environmental Analytical Chemistry meeting on LC/MS. The three day meeting, includes short courses held at Montreux, Switzerland.
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Mass Spectral Molecular Weight - This site lists mass occurrence probabilities and gives simple rules for upper and lower limits to the molecular weight of an unknown from mass spectral data. Relevant publications are listed.
Meta Description: [ MOLECULAR WEIGHTS FROM MASS SPECTRAL DATA, EXPERT SYSTEMS FOR MOLECULAR WEIGHTS, MASS OCCURRENCE PROBABILITIES ]
Mass Spectrometry and Biotechnology Resource - Provides reference materials for scientists working with mass spectrometry in the biotechnology industry.
Meta Description: [ A mass spectrometry and biotechnology resource web site, featured are printable reference tables and chemistry topics. ]
Mass Spectrometry Blog - Web log of MS web sites and other links and items of interest, maintained from Department of Chemistry Louisiana State University.
Meta Description: [ A Web log of mass spectrometry Web sites, discussion groups, mailing lists and other links and items of interest to the mass spectrometry community ]
Mobile Miniature Mass Spectrometer - Resource focusing on field-portable MS instruments, with classification by probe, links to project, development, MSDS, software and databases.
Meta Description: [ Commented links to miniature mass spectrometer and mobile GC/MS ]
Network Developing Forensic Applications of Stable Isotope Mass Spectrometry - Overview of techniques and information about the second conference. Maintained at the University of Reading, England.
NIST Polymers Division: Maldi Recipes - Matrix assisted laser desorption ionization application to polymer science. Includes links to meetings and presentations by researcher in field, at Gaithersburg, Maryland.
Meta Description: [ NIST Materials Science and Engineering Laboratory - Polymers Division MALDI Recipes ]
Sci Techniques Mass Spec - Archives of forum, with categories for groups, troubleshooting, tutorials, professional, societies, listservers, journals, companies, supplies and services, maintained at Georgia Institute of Technology, Atlanta.
Selected Ion Flow Tube Mass Spectrometry - Introduction to SIFT-MS for trace gas analysis of air, breath and liquid headspace, in medicine, biology and environmental applications. Includes links to related articles.
Time Of Flight Mass Spectrometer Tutorial - Stepwise guide on the fundamentals of the method through ionisation, acceleration and detection, and instrument components required, by manufacturer and supplier R M Jordan Co Inc, Grass Valley, California.
Meta Description: [ Time Of Flight Mass Spectrometer Tutorial by Jordan TOF Products, Inc. This is an instructional tutorial dealing with the fundamentals of Time of Flight (TOF) technology. ]
Underwater Mass Spectrometry - Information and talks from the Workshop on Harsh-Environment Mass Spectrometry, hosted by the Center for Ocean Technology at the University of South Florida.
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