Clinical Chemistry current issue

[Editorials] Reporting Bias in Diagnostic and Prognostic Studies: Time for Action
Rifai, N., Altman, D. G., Bossuyt, P. M. Tue, 01 Jul 2008 00:00:00 -0000

[Editorials] New Horizons for Diagnostic Applications of Circulating Nucleosomes in Blood?
Holdenrieder, S., Kolligs, F. T., Stieber, P. Tue, 01 Jul 2008 00:00:00 -0000

[Editorials] Use of Biomarkers to Predict Cardiac Risk from Medications: Getting to the Heart of the Matter
Januzzi, J. L. Tue, 01 Jul 2008 00:00:00 -0000

[Perspectives] Low Testosterone and Risk of Premature Death in Older Men: Analytical and Preanalytical Issues in Measuring Circulating Testosterone
Platz, E. A. Tue, 01 Jul 2008 00:00:00 -0000

[Perspectives] Cut Points for Lipids and Lipoproteins in Children and Adolescents: Should They Be Reassessed?
Kwiterovich, P. O. Tue, 01 Jul 2008 00:00:00 -0000

[Review] Microarray Technology and Applications in the Arena of Genome-Wide Association
Grant, S. F. A., Hakonarson, H. Tue, 01 Jul 2008 00:00:00 -0000
Background: There is a revolution occurring in single nucleotide polymorphism (SNP) genotyping technology, with high-throughput methods now allowing large numbers of SNPs (105–106) to be genotyped in large cohort studies. This has enabled large-scale genome-wide association (GWA) studies in complex diseases, such as diabetes, asthma, and inflammatory bowel disease, to be undertaken for the first time. Content: The GWA approach serves the critical need for a comprehensive and unbiased strategy to identify causal genes related to complex disease, and is rapidly replacing the more traditional candidate gene studies and microsatellite-based linkage mapping approaches that have dominated gene discovery attempts for common diseases. As a consequence of employing array-based technologies, over the last 3 years dramatic discoveries of key variants involved in multiple complex diseases and related traits have been reported in the top scientific literature and, most importantly, have been largely replicated by independent investigator groups. As a consequence, several novel genes have been identified, most notably in the metabolic, cardiovascular, autoimmune, and oncology disease areas, that are clearly rooted in the biology of these disorders. These discoveries have opened up new avenues for investigators to address novel molecular pathways that were not previously linked to or thought of in relation with these diseases. Summary: This review provides a synopsis of recent advances and what we may expect to still emerge from this field.

 

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International University Chemistry Departments - A collaborative project where each country is indexed by a webmaster in that country.
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Department of Chemistry, Israel Institute of Technology - Information on undergraduate and graduate study, research and academic staff.

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