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Toxicodendron is a small genus of woody trees, shrubs and vines, all of which produce the skin-irritating oil urushiol, which can cause a severe allergic reaction; hence the scientific name which means "poison tree".

Members of this genus are very often included in the genus Rhus. As genetic studies show that Rhus without Toxicodendron is paraphyletic, this is the better treatment to follow botanically, but there is some practical convenience in having the highly allergenic species listed separately.

They have pinnately compound, alternate leaves and whitish or grayish drupes. The best known member is poison-ivy, practically ubiquitous throughout much of North America.

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