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A toxin (Gk. toxikon "(poison) for use on arrows,") is a poisonous substance produced by living cells or organisms. Toxins are nearly always proteins that are capable of causing disease on contact or absorption with body tissues by interacting with biological macromolecules such as enzymes or cellular receptors. Toxins vary greatly in their severity, ranging from usually minor and acute (as in a bee sting) to almost immediately deadly (as in botulinum toxin).

Biotoxins vary greatly in purpose and mechanism, and can be highly complex (the venom of the cone snail contains dozens of small proteins, each targeting a specific nerve channel or receptor), or relatively small protein.

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Biotoxins are used in nature for two primary reasons:

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404 Naturally Occurring Toxic Factors - List of abstracts of the United States Department of Agriculture, Agricultural Research Service.
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