Bioinformatics - current issue

A novel CHHC Zn-finger domain found in spliceosomal proteins and tRNA modifying enzymes
Andreeva, A., Tidow, H. Mon, 06 Oct 2008 00:00:00 -0000
Summary: We report a previously uncharacterized CHHC Zn-finger domain identified in spliceosomal U11-48K proteins, tRNA methyl-transferases TRM13 and gametocyte specific factors. We show that this domain behaves as an independent folding unit and that it stoichiometrically binds zinc in a one-to-one ratio. Based on the conserved sequence features we predict that this domain may function as a RNA recognition and binding module. Contact: tony@mrc-lmb.cam.ac.uk Supplementary information: Supplementary data are available on Bioinformatics online.

 

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