Gourt > Science > Biology > Bioinformatics (23)
Bioinformatics and computational biology involve the use of techniques from applied mathematics, informatics, statistics, and computer science to solve biological problems. Research in computational biology often overlaps with systems biology. Major research efforts in the field include sequence alignment, gene finding, genome assembly, protein structure alignment, protein structure prediction, prediction of gene expression and protein-protein interactions, and the modeling of evolution.
The terms bioinformatics and computational biology are often used interchangeably, although the former typically focuses on algorithm development and specific computational methods, while the latter focuses more on hypothesis testing and discovery in the biological domain. Although this distinction is used by National Institutes of Health in their working definitions of Bioinformatics and Computational Biology, it is clear that there is a tight coupling of developments and knowledge between the more hypothesis-driven research in computational biology and technique-driven research in bioinformatics. Computational biology also includes lesser known but equally important subdisciplines such as computational biochemistry and computational biophysics.
A common thread in projects in bioinformatics and computational biology is the use of mathematical tools to extract useful information from noisy data produced by high-throughput biological techniques such as genomics (The field of data mining overlaps with computational biology in this regard). A representative problem in bioinformatics is the assembly of high-quality DNA sequences from fragmentary "shotgun" DNA sequencing, while in computational biology, a representative problem might be statistical testing of a hypothesis of common gene regulation using data from mRNA microarrays or mass spectrometry.
More on [ Bioinformatics ]
Informatics :: Medicine
Proteomics :: Proteins and Enzymes
Human :: Mammal
Informatics :: Biodiversity
Lost in translation: an assessment and perspective for computational microRNA target identification
Alexiou, P., Maragkakis, M., Papadopoulos, G. L., Reczko, M., Hatzigeorgiou, A. G. MicroRNAs (miRNAs) are a class of short endogenously expressed RNA molecules that regulate gene expression by binding directly to the messenger RNA of protein coding genes. They have been found to confer a novel layer of genetic regulation in a wide range of biological processes. Computational miRNA target prediction remains one of the key means used to decipher the role of miRNAs in development and disease. Here we introduce the basic idea behind the experimental identification of miRNA targets and present some of the most widely used computational miRNA target identification programs. The review includes an assessment of the prediction quality of these programs and their combinations. Contact: p.alexiou@fleming.gr Supplementary information: Supplementary data are available at Bioinformatics online.
The Bioinformatics Organization, Inc. - Bioinformatics society open to all people. Strong emphasis on open access to biological information as well as Free and Open Source software.
The Ensembl Project - Ensembl is a joint project between EMBL-EBI and the Sanger Centre to develop a software system which produces and maintains automatic annotation on eukaryotic genomes.
Bioinformatics and Biological Computing - Comprehensive bioinformatics site, with access to multiple database searching and sequence analysis tools - from the Weizmann Institute of Science.
Meta Description: [ Bioinformatics and Biological Computing ]
Bioinformatics Resources - Resource for searching genetic databases, online tools, journals, and recent news.
DNA Structural Atlas - Easy-to-use summary of genomic information currently available for all organisms-from the Technical Univ. of Denmark.
European Molecular Biology Network - EMBnet is the only organisation world-wide bringing bioinformatics professionals to work together to serve the expanding fields of genetics and molecular biology.
Society for Bioinformatics in the Nordic Countries - SocBiN is a non-profit organisation for people working with and interested in bioinformatics. One task of the society is to arrange annual conferences on Bioinformatics.
The International Society for Computational Biology - The International Society for Computational Biology is dedicated to advancing the scientific understanding of living systems through computation; the emphasis is on the role of computing and informatics in advancing molecular biology.
Wikiomics - Editable by the whole bioinformatics community, Wikiomics provides bioinformatics tutorials and reviews that are kept up-to-date by the readers themselves.
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