Gourt > Science > Biology > Biochemistry and Molecular Biology > Gene Expression > RNA Interference (1)
RNA interference (RNAi) is a mechanism in molecular biology where the presence of certain fragments of double-stranded RNA (dsRNA) interferes with the expression of a particular gene which shares a homologous sequence with the dsRNA. RNAi is distinct from other gene silencing phenomena in that silencing can spread from cell to cell and generate heritable phenotypes in first generation progeny when used in Caenorhabditis elegans.
Before RNAi was well characterized, it was called by other names, including post transcriptional gene silencing and transgene silencing. Only after these phenomena were characterized at the molecular level was it obvious that they were the same phenomenon.
The use of RNA to reduce expression in plants has been a common procedure for many years. Single-stranded antisense RNA was introduced into plant cells that hybridized to the cognate, single-stranded, sense messenger RNA. While scientists first believed that the resulting dsRNA helix could not be translated into a protein, it is now clear that the dsRNA triggered the RNAi response. The use of dsRNA became more widespread after the discovery of the RNAi machinery, first in petunias and later in roundworms (C. elegans).
More on [ RNA interference ]
RNA Interference » mortgage refinancing: Jessica Castro asked: RNA interference (RNAi) or double-stranded RNA (.. http://bit.ly/5iXR6x
hugusar (Hugo Russell) Sat, 05 Dec 2009 00:11:22 -0000
RNA Interference » mortgage refinancing: Jessica Castro asked: RNA interference (RNAi) or double-stranded RNA (.. http://bit.ly/5iXR6x
Mortgage Refinancing Tips: RNA Interference » mortgage refinancing http://bit.ly/5iXR6x
hugusar (Hugo Russell) Fri, 04 Dec 2009 18:34:03 -0000
Mortgage Refinancing Tips: RNA Interference » mortgage refinancing http://bit.ly/5iXR6x
RT @DailyReckoning: Now is the Time to Invest in RNAi: The science of RNA interference is moving rapidly toward marketable cures. Our D. ...
MoneyWeekFrance (MoneyWeek France) Fri, 04 Dec 2009 08:33:22 -0000
RT @DailyReckoning: Now is the Time to Invest in RNAi: The science of RNA interference is moving rapidly toward marketable cures. Our D. ...
Now is the Time to Invest in RNAi: The science of RNA interference is moving rapidly toward marketable cures. Our D... http://bit.ly/7nwKAC
AgoraFinancial (Agora Financial) Fri, 04 Dec 2009 00:00:48 -0000
Now is the Time to Invest in RNAi: The science of RNA interference is moving rapidly toward marketable cures. Our D... http://bit.ly/7nwKAC
Now is the Time to Invest in RNAi: The science of RNA interference is moving rapidly toward marketable cures. Our D... http://bit.ly/7nwKAC
DailyReckoning (The Daily Reckoning) Fri, 04 Dec 2009 00:00:47 -0000
Now is the Time to Invest in RNAi: The science of RNA interference is moving rapidly toward marketable cures. Our D... http://bit.ly/7nwKAC
You know, RNA interference isn't just for silencing human RNA synthase my peeps, http://www.plantphysiol.org/cgi/content/abstract/144/3/1520
virun (Philip J. Bromley) Thu, 03 Dec 2009 22:27:23 -0000
You know, RNA interference isn't just for silencing human RNA synthase my peeps, http://www.plantphysiol.org/cgi/content/abstract/144/3/1520
A TV Show on RNAi by PBS - NOVA scienceNOW TV program describes RNAi as a major breakthrough in gene therapy with enormous medical promise. Provides basic overview of RNAi technology, current therapeutic approaches, and interview with the experts in the field. Includes 15-minutes TV broadcast segment on RNAi.
Meta Description: [ Ask expert Greg Hannon questions about RNA interference, experience an interactive explanation of how RNAi works, view a slide show of its potential therapeutic applications, read related science news, and view the NOVA scienceNOW broadcast segment. ]
500
Article on RNAi by GNN - Online article describing gene silencing mechanism and how RNAi can be used for HIV treatment.
Article on RNAi by HOPES - Online article describes basic mechanism of RNAi and how it can be applied for Huntington's disease treatment.
Meta Description: [ HOPES provides accurate, up-to-date, scientific information about Huntington's disease ]
Cambridge Healthtech Institute - CHI organizes RNAi-related conferences throughout the US and Europe, including therapeutics, pharmaceutics, drug development, target discovery, and biodefense. Provides biotechnology news and conferences information.
Meta Description: [ CHI’s renowned conferences are the underpinning for all our other information resources. Each year, approximately 100 conferences are held throughout the US and Europe | . Molecular Medicine Tri-Conference · Beyond Genome · PepTalk: The Protein Information Week · World Pharmaceutical Congr... ]
Cenix BioScience GmbH - Develops RNA-mediated Interference (RNAi) technology for the discovery of conventional therapeutics. Biological research data and company information is provided.
Meta Description: [ Cenix BioScience is pioneering RNA-mediated interference (RNAi) for the discovery of conventional therapeutics and the development of the exciting new class of RNAi-based medicines. ]
Drosophila RNAi Resource - Informational RNAi resource on studying drosophila genes and their roles in development by Society for Developmental Biology.
Gene Silencing Mechanism - Animation of post transcriptional gene silencing or RNA Interference (RNAi) by Nature Reviews Genetics.
Induction of an interferon response by RNAi vectors in mammalian cells - Article from journal Nature Genetics about potential complications of use of RNAi vector-based technology for therapeutics.
500
InFocus RNAi Web Broadcast by Bio.com - RNAi Advances In 2005: Technologies And Applications. Bio.com provides an online RNAi technology-focused webcast, experts in the field discuss new insights into the regulation of gene expression by RNAi. Includes event description and downloadable webcast.
Isis Pharmaceuticals Inc. - Discovers and develops drugs based upon antisense and RNAi technology. Focused on RNA as a therapeutic target. Includes overview of recent research and drug development approaches.
Navigating Journey of Genome to Medicine - Review article on RNAi by International Herald Tribune. Provides an overview on RNA Interference discovery, current research efforts, and therapeutic potential.
Meta Description: [ When the human genome was sequenced, the project's promise of curing disease depended in part on cells' natural ability to "turn off" genes. ]
Oligonucleotide Therapeutic Society - Society host conferences on academia and industry-based research and development of oligonucleotide therapeutics: RNAi, antisense, and others. Provides society overview, publication materials, meetings, and contact information.
Meta Description: [ Oglionucletide Theraputic Society, Inc., is....... ]
Pharmaceutical Discovery - Peer-review online journal publishing articles on recent advances in life sciences research and drug discovery. Includes RNAi related news, overview of new technology, and research articles.
Meta Description: [ Pharma DD serves the global genomics/proteomics
community by bridging the gap between life sciences research and drug
discovery. Pharma DD provides current information about
methodologies, technologies and laboratory productivity. ]
Protein Lounge - Provides database that contains targets against mRNA sequences throughout a variety of organisms. Includes gene search option, and disease-specific siRNA genes.
404
Published siRNA Database - Listing published sequences of siRNA's with literature reference for each citation.
RNA Interference at Journal Nature - Focus RNA Interference - online resource publishing recent advances in RNAi field, and novel applications in Nature Cell Biology and Nature Reviews.
Meta Description: [ RNA interference: A Nature Reviews journals web focus on RNAi - a selection of recently published Reviews, Perspectives and Highlights on this topic. ]
RNAi BioForum - Online forum for siRNA, microRNA and RNAi methods discussion.
Meta Description: [ Biology Forum Discussion ]
RNAi Database - Contains all siRNA from C. elegans including assay, resulting phenotypes, dsRNA target location. Database provides Gene/Protein or Phenotype search options.
RNAi Mechanism Animation by Journal Nature - An animation from Nature Publishing Group on the mechanism of RNA Interference (RNAi).
Meta Description: [ RNA interference: A Nature Reviews journals web focus on RNAi - a selection of recently published Reviews, Perspectives and Highlights on this topic. ]
404
RNAi Meeting at Cold Spring Harbor Laboratory - Conference on RNA Interference (RNAi) and eukaryotic mRNA processing. Meeting focus on the mechanisms and regulation of RNA interference and related mechanisms. Provides information regarding meeting registration, program, and discussion topics.
RNAi Meeting: For Functional Analysis and Target Validation - Discovery on Target RNAi meeting organized by Cambridge Healthtech Institute at Boston, Massachusetts, October 19-20, 2005. Meeting provides overview of various aspects in RNA Interference (RNAi) research, ranging from in vitro and in vivo drug discovery research to therapeutic applications. Online meeting information is available: plenary sessions, exhibits, and poster presentations.
Meta Description: [ CHI's Discovery on Target is will focus on disease target identification and effectiveness. ]
RNAi News - Online resource for scientists, researchers, technologists, and executives engaged in RNA Interference, functional genomics, and drug discovery. Offers industry news, product reviews, and meetings information.
RNAi Research and Therapeutics Conference - Meeting organized by GTCbio with main focus on RNA Interference. Purpose of the conference is to facilitate the exchange of biopharmaceutical and biomedical intelligence between industry leaders, academic and government organizations, and the financial community. Provides meeting agenda, poster session and registration information.
Meta Description: [ Conferences satisfy the need for scientific, technology and business information exchange of biopharmaceutical and biomedical companies or institutions. ]
RNAi Resource at Ambion - Online RNA Interference (RNAi) resource. Provide scientific and technical support, information on microRNA and small interfering RNA application in gene expression research.
Meta Description: [ A gateway to all types of information about RNA interference (RNAi), including articles, products, news, events, and other websites. ]
RNAi Resource at Macalester College - Informational resource, including RNAi mechanism, overview of current studies, and related research protocols.
RNAi Therapeutics: How Likely, How Soon? - Review article from PLoS Biology journal. Describes mechanism of RNA Interference, potential applications towards therapeutics, and current problems associated with delivery.
Meta Description: [ PLoS Biology is an open-access, peer-reviewed journal that features works of exceptional significance in all areas of biological science, from molecules to ecosystems, including works at the interface with other disciplines. ]
RNAi Therapies by Nature Medicine Journal - Article on RNAi therapy potential describing advantages for novel drug discovery and safety concerns.
RNAi Transfection Resource - Review of transfection techniques such as electroporation, denrimers and lipids that are used for transfection of DNA, RNA, and siRNA. Includes information on optimized cell type specific transfection systems.
RNAi.net - Online resource offering information RNA interference and related issues: news, interviews, articles, techniques.
Meta Description: [ News, posters, events and suppliers from the main portal site for the field of RNAi research. ]
RNAi@elegansNet - Directory on gene silencing by RNA interference (RNAi) literature and resources.
Meta Description: [ Gene silencing by RNA interference (RNAi) literature and resources using selected links or top search and clustering engines. ]
Rosetta Genomics - Israel-based microRNA genomics company, develops bioinformatic tools for miRNA gene detection approach.
Meta Description: [ תיאור של קטגורייה ]
SBS Conference - The Society for Biomolecular Screening holds a conference on high-throughput RNAi screening approach using siRNA/shRNA libraries on September 11-15, 2005.
TargetScan - Online software provided by MIT for prediction of microRNA targets. Provides research data and online software for microRNA target identification and analysis.
Meta Description: [ TargetScan: prediction of microRNA targets ]
The microRNA Registry - Online resource provides a service for the assignment of miRNA gene names. Provides searchable database of published miRNA sequences. Includes data and research application information.
The RNAi vs. HIV - Reviews the use of this therapy in fighting HIV. Includes mechanism, difficulties, terms, and featured experiments.
Meta Description: [ This educational site discusses the effectiveness of RNA Interference against HIV ]
The RNAi Web - Online resource for RNA Interference (RNAi) technology. Offers overview of technology, references, and links on other RNAi-related web resources.
Meta Description: [ The RNAi Web - Resource center for RNA interference technology. It offers scientific and technical information on RNAi technology, guidelines and tips on siRNA design, and also collects RNAi related web resources ]
Transcriptional Gene Silencing - Mechanisms of TGS by Kevin Morris laboratory. Includes description of HIV research performed using lentiviral vector gene therapy and RNAi mediated gene silencing.
Wikipedia Article on RNAi - Online article describing the basics of RNA Interference (RNAi) mechanism.
| genomics humanimag | |
| Next Video | |
